Welcome to the Gerarduzzi Lab

Kidney Fibrosis

Our lab is interested in studying novel proteins and their mechanisms in kidney repair after injury and their implications in renal fibrosis during early adaptive repair and into late stage disease.

Matrix Biology

The extracellular matrix is a dynamic and flexible structure that plays a crucial role in maintaining cellular homeostasis by mediating outside external signals to the surrounding cells. Understanding the cross-talk between cell-ECM interactions is key to studying a variety of pathologies which stem a dysregulated cell matrix.

Pediatric Leukemia

Both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are known to have a blockage in p53 function, which hinders conventional therapies like chemo- and radio-therapy. Our lab is interested in studying p53 regulation in leukemia with the goal of developing new strategies to restore p53 function necessary for cancer treatments.